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Gene: Tfpi (tissue factor pathway inhibitor) Rattus norvegicus
Symbol: Tfpi
Name: tissue factor pathway inhibitor
Description: Predicted to have serine-type endopeptidase inhibitor activity. Involved in cellular response to interleukin-1; cellular response to lipopolysaccharide; and response to estradiol. Localizes to extracellular space. Biomarker of atrial fibrillation; disseminated intravascular coagulation; myocardial infarction; and osteonecrosis. Human ortholog(s) of this gene implicated in several diseases, including factor VIII deficiency; osteonecrosis; thrombophilia (multiple); toxic shock syndrome; and transient cerebral ischemia. Orthologous to human TFPI (tissue factor pathway inhibitor); PARTICIPATES IN coagulation cascade pathway; syndecan signaling pathway; complement system pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: EPI; extrinsic pathway inhibitor; LACI; lipoprotein-associated coagulation inhibitor; tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Homo sapiens (human) : TFPI (tissue factor pathway inhibitor)  HGNC  Alliance
Mus musculus (house mouse) : Tfpi (tissue factor pathway inhibitor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tfpi (tissue factor pathway inhibitor)
Pan paniscus (bonobo/pygmy chimpanzee) : TFPI (tissue factor pathway inhibitor)
Canis lupus familiaris (dog) : TFPI (tissue factor pathway inhibitor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tfpi (tissue factor pathway inhibitor)
Sus scrofa (pig) : TFPI (tissue factor pathway inhibitor)
Chlorocebus sabaeus (African green monkey) : TFPI (tissue factor pathway inhibitor)
Heterocephalus glaber (naked mole-rat) : Tfpi (tissue factor pathway inhibitor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0371,852,738 - 71,902,127 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl371,852,744 - 71,893,618 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,373,808 - 78,423,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4367,654,389 - 67,697,178 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1367,550,760 - 67,593,550 (-)NCBI
Celera368,890,124 - 68,933,788 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Tfpi
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61914
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.