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Gene: Aif1 (allograft inflammatory factor 1) Rattus norvegicus
Symbol: Aif1
Name: allograft inflammatory factor 1
Description: Predicted to have actin filament binding activity and calcium ion binding activity. Involved in several processes, including cellular response to morphine; positive regulation of muscle hyperplasia; and positive regulation of nitrogen compound metabolic process. Localizes to cytosol; lamellipodium; and perikaryon. Predicted to colocalize with actin filament and ruffle membrane. Used to study type 1 diabetes mellitus. Biomarker of brain disease (multiple); glomerulonephritis; meningoencephalitis; and motor neuron disease. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human AIF1 (allograft inflammatory factor 1); INTERACTS WITH (+)-pilocarpine; (S)-colchicine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AIF-1; balloon angioplasty responsive transcript; balloon angioplasty-responsive transcript 1; BART-1; Bart1; iba1; ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule 1; microglia response factor; mrf-1
Homo sapiens (human) : AIF1 (allograft inflammatory factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Aif1 (allograft inflammatory factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aif1 (allograft inflammatory factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AIF1 (allograft inflammatory factor 1)
Canis lupus familiaris (dog) : AIF1 (allograft inflammatory factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aif1 (allograft inflammatory factor 1)
Sus scrofa (pig) : AIF1 (allograft inflammatory factor 1)
Heterocephalus glaber (naked mole-rat) : Aif1 (allograft inflammatory factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0205,161,350 - 5,167,176 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,161,333 - 5,166,448 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,234,609 - 7,240,454 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,714,428 - 3,716,327 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1203,714,654 - 3,716,552NCBI
Celera204,373,127 - 4,375,026 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Aif1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61924
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.