Gene: Aif1 (allograft inflammatory factor 1) Rattus norvegicus
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Symbol: Aif1
Name: allograft inflammatory factor 1
Description: Predicted to have actin filament binding activity and calcium ion binding activity; involved in several processes, including cellular response to extracellular stimulus, cellular response to hormone stimulus, and positive regulation of cellular metabolic process; localizes to the cytosol, lamellipodium, and perikaryon; predicted to colocalize with the actin filament and ruffle membrane; used to study type 1 diabetes mellitus; biomarker of brain disease (multiple), cerebrovascular disease (multiple), glomerulonephritis, meningoencephalitis, and motor neuron disease; orthologous to human AIF1 (allograft inflammatory factor 1); INTERACTS WITH (+)-pilocarpine; (RS)-amphetamine; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AIF-1; balloon angioplasty responsive transcript; balloon angioplasty-responsive transcript 1; BART-1; Bart1; iba1; ionized calcium binding adapter molecule 1; ionized calcium-binding adapter molecule 1; microglia response factor; mrf-1
Orthologs:
Homo sapiens (human) : AIF1 (allograft inflammatory factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Aif1 (allograft inflammatory factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aif1 (allograft inflammatory factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AIF1 (allograft inflammatory factor 1)
Canis lupus familiaris (dog) : AIF1 (allograft inflammatory factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aif1 (allograft inflammatory factor 1)
Sus scrofa (pig) : AIF1 (allograft inflammatory factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0205,161,350 - 5,167,176 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0207,234,609 - 7,240,454 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,714,428 - 3,716,327 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1203,714,654 - 3,716,552NCBI
Celera204,373,127 - 4,375,026 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Aif1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61924
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.