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Gene: Fah (fumarylacetoacetate hydrolase) Rattus norvegicus
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Symbol: Fah
Name: fumarylacetoacetate hydrolase
Description: Predicted to have fumarylacetoacetase activity. Predicted to be involved in carboxylic acid catabolic process. Predicted to localize to the cytosol. Used to study liver cirrhosis and tyrosinemia type I. Biomarker of hypertension. Human ortholog(s) of this gene implicated in tyrosinemia and tyrosinemia type I. Orthologous to human FAH (fumarylacetoacetate hydrolase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: beta-diketonase; FAA; fumarylacetoacetase
Orthologs:
Homo sapiens (human) : FAH (fumarylacetoacetate hydrolase)  HGNC  Alliance
Mus musculus (house mouse) : Fah (fumarylacetoacetate hydrolase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fah (fumarylacetoacetate hydrolase)
Pan paniscus (bonobo/pygmy chimpanzee) : FAH (fumarylacetoacetate hydrolase)
Canis lupus familiaris (dog) : FAH (fumarylacetoacetate hydrolase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fah (fumarylacetoacetate hydrolase)
Sus scrofa (pig) : FAH (fumarylacetoacetate hydrolase)
more info ...
Allele / Splice: Fahem3Mcwi   Fahem15Dlli-/-   Fahem10Dlli-/-  
Genetic Models: SD-Fahem10Dlli-/- SD-Fahem15Dlli-/- SD-Fahem3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01146,713,663 - 146,736,339 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01147,640,316 - 147,662,920 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41140,851,975 - 140,876,187 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11140,930,382 - 140,954,593 (-)NCBI
Celera1130,566,888 - 130,589,532 (-)NCBICelera
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Fah
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61932
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-05-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.