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Gene: Pak2 (p21 (RAC1) activated kinase 2) Rattus norvegicus
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Symbol: Pak2
Name: p21 (RAC1) activated kinase 2
Description: Predicted to have several functions, including enzyme binding activity; identical protein binding activity; and protein tyrosine kinase activator activity. Involved in cardiac muscle hypertrophy and cellular response to transforming growth factor beta stimulus. Localizes to the secretory granule. Biomarker of ureteral obstruction. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2); PARTICIPATES IN vascular endothelial growth factor signaling pathway; epidermal growth factor/neuregulin signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,4,6-trinitrobenzenesulfonic acid; 2-ethoxyethanol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: gamma-PAK; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; PAK-2; serine/threonine-protein kinase PAK 2
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01172,829,407 - 72,865,815 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01175,895,329 - 75,939,106 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,529,961 - 70,588,511 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11170,587,549 - 70,646,100 (+)NCBI
Celera1168,130,464 - 68,189,144 (+)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pak2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61953
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.