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Gene: NOS1 (nitric oxide synthase 1) Homo sapiens
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Symbol: NOS1
Name: nitric oxide synthase 1
Description: Exhibits nitric-oxide synthase activity. Involved in several processes, including multicellular organismal response to stress; positive regulation of peptidyl-serine phosphorylation; and vasodilation. Localizes to the nucleoplasm; sarcolemma; and sarcoplasmic reticulum. Predicted to colocalize with the ryanodine receptor complex. Implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Biomarker of Duchenne muscular dystrophy; chronic obstructive pulmonary disease; cystic fibrosis; and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bNOS; constitutive NOS; IHPS1; N-NOS; NC-NOS; neuronal NOS; nitric oxide synthase 1 (neuronal); nitric oxide synthase, brain; nNOS; NOS; NOS type I; peptidyl-cysteine S-nitrosylase NOS1
Orthologs:
Mus musculus (house mouse) : Nos1 (nitric oxide synthase 1, neuronal)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nos1 (nitric oxide synthase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nos1 (nitric oxide synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NOS1 (nitric oxide synthase 1)
Canis lupus familiaris (dog) : NOS1 (nitric oxide synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nos1 (nitric oxide synthase 1)
Sus scrofa (pig) : NOS1 (nitric oxide synthase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812117,208,142 - 117,361,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712117,645,921 - 117,799,607 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612116,135,362 - 116,283,965 (-)NCBINCBI36hg18NCBI36
Build 3412116,113,698 - 116,262,302NCBI
Celera12117,280,475 - 117,430,209 (-)NCBI
Cytogenetic Map12q24.22NCBI
HuRef12114,655,115 - 114,808,727 (-)NCBIHuRef
CHM1_112117,611,241 - 117,767,258 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NOS1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619551
Created: 2002-07-23
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.