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Gene: Crebbp (CREB binding protein) Mus musculus
Symbol: Crebbp
Name: CREB binding protein
Description: Exhibits several functions, including disordered domain specific binding activity; protein heterodimerization activity; and transcription factor binding activity. Predicted to contribute to DNA-binding transcription factor activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; face morphogenesis; and regulation of macromolecule biosynthetic process. Localizes to the condensed chromosome outer kinetochore and nucleus. Used to study Rubinstein-Taybi syndrome; acute myeloid leukemia; autism spectrum disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute myeloid leukemia; and precursor lymphoblastic lymphoma/leukemia. Is expressed in several structures, including central nervous system; genitourinary system; heart; liver; and lung epithelium. Orthologous to human CREBBP (CREB binding protein); PARTICIPATES IN aldosterone signaling pathway; androgen signaling pathway; cortisol signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW558298; CBP; CBP/p300; CREB-binding protein; histone lysine acetyltransferase CREBBP; KAT3A; p300/CBP; protein-lysine acetyltransferase CREBBP
Homo sapiens (human) : CREBBP (CREB binding protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Crebbp (CREB binding protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crebbp (CREB binding protein)
Pan paniscus (bonobo/pygmy chimpanzee) : CREBBP (CREB binding protein)
Canis lupus familiaris (dog) : CREBBP (CREB binding protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crebbp (CREB binding protein)
Sus scrofa (pig) : CREBBP (CREB binding protein)
Chlorocebus sabaeus (African green monkey) : CREBBP (CREB binding protein)
Heterocephalus glaber (naked mole-rat) : Crebbp (CREB binding protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl164,081,328 - 4,213,997 (-)Ensembl
GRCm38164,081,334 - 4,213,957 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37164,084,048 - 4,213,404 (-)NCBIGRCm37mm9NCBIm37
MGSCv36163,999,276 - 4,128,632 (-)NCBImm8
Celera164,716,365 - 4,845,799 (-)NCBICelera
Cytogenetic Map16 A1NCBI
cM Map162.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Crebbp
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619553
Created: 2002-07-23
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.