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Gene: Crebbp (CREB binding protein) Mus musculus
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Symbol: Crebbp
Name: CREB binding protein
Description: Exhibits several functions, including disordered domain specific binding activity; protein heterodimerization activity; and transcription factor binding activity. Predicted to contribute to DNA-binding transcription factor activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; face morphogenesis; and regulation of macromolecule biosynthetic process. Localizes to the condensed chromosome outer kinetochore and nucleus. Used to study Rubinstein-Taybi syndrome; acute myeloid leukemia; autism spectrum disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute myeloid leukemia; and precursor lymphoblastic lymphoma/leukemia. Is expressed in several structures, including central nervous system; genitourinary system; heart; liver; and lung epithelium. Orthologous to human CREBBP (CREB binding protein); PARTICIPATES IN aldosterone signaling pathway; androgen signaling pathway; cortisol signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AW558298; CBP; CBP/p300; CREB-binding protein; histone lysine acetyltransferase CREBBP; KAT3A; p300/CBP; protein-lysine acetyltransferase CREBBP
Orthologs:
Homo sapiens (human) : CREBBP (CREB binding protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Crebbp (CREB binding protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Crebbp (CREB binding protein)
Pan paniscus (bonobo/pygmy chimpanzee) : CREBBP (CREB binding protein)
Canis lupus familiaris (dog) : CREBBP (CREB binding protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Crebbp (CREB binding protein)
Sus scrofa (pig) : CREBBP (CREB binding protein)
Chlorocebus sabaeus (African green monkey) : CREBBP (CREB binding protein)
Heterocephalus glaber (naked mole-rat) : Crebbp (CREB binding protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl164,081,328 - 4,213,997 (-)Ensembl
GRCm38164,081,334 - 4,213,957 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37164,084,048 - 4,213,404 (-)NCBIGRCm37mm9NCBIm37
MGSCv36163,999,276 - 4,128,632 (-)NCBImm8
Celera164,716,365 - 4,845,799 (-)NCBICelera
Cytogenetic Map16 A1NCBI
cM Map162.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Crebbp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619553
Created: 2002-07-23
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.