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Gene: VDR (vitamin D receptor) Homo sapiens
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Symbol: VDR
Name: vitamin D receptor
Description: Exhibits several functions, including lithocholic acid receptor activity; nuclear receptor activity; and steroid binding activity. Contributes to DNA-binding transcription factor activity and vitamin D response element binding activity. Involved in several processes, including decidualization; negative regulation of keratinocyte proliferation; and regulation of transcription by RNA polymerase II. Localizes to cytosol; nucleus; and receptor complex. Implicated in several diseases, including autoimmune hypersensitivity disease (multiple); lipid storage disease (multiple); liver disease (multiple); melanoma (multiple); and tuberculosis (multiple). Biomarker of several diseases, including autosomal recessive limb-girdle muscular dystrophy type 2B; basal cell carcinoma; cholangitis (multiple); esophagus adenocarcinoma; and non-alcoholic fatty liver disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1,25-dihydroxyvitamin D3 receptor; NR1I1; nuclear receptor subfamily 1 group I member 1; PPP1R163; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin d (1,25-dihydroxyvitamin d3) receptor; vitamin D nuclear receptor variant 1; vitamin D3 receptor
Orthologs:
Mus musculus (house mouse) : Vdr (vitamin D (1,25-dihydroxyvitamin D3) receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Vdr (vitamin D receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vdr (vitamin D receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : VDR (vitamin D receptor)
Canis lupus familiaris (dog) : VDR (vitamin D receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vdr (vitamin D receptor)
Sus scrofa (pig) : VDR (vitamin D receptor)
Chlorocebus sabaeus (African green monkey) : VDR (vitamin D receptor)
Heterocephalus glaber (naked mole-rat) : Vdr (vitamin D receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1247,841,537 - 47,943,048 (-)EnsemblGRCh38hg38GRCh38
GRCh381247,841,537 - 47,905,022 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371248,235,320 - 48,298,814 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361246,521,587 - 46,585,081 (-)NCBINCBI36hg18NCBI36
Build 341246,521,588 - 46,585,036NCBI
Celera1247,032,871 - 47,096,518 (-)NCBI
Cytogenetic Map12q13.11NCBI
HuRef1245,266,368 - 45,330,677 (-)NCBIHuRef
CHM1_11248,201,212 - 48,264,704 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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