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Gene: ERBB2 (erb-b2 receptor tyrosine kinase 2) Homo sapiens
Symbol: ERBB2
Name: erb-b2 receptor tyrosine kinase 2
Description: Exhibits several functions, including enzyme binding activity; protein C-terminus binding activity; and protein heterodimerization activity. Contributes to growth factor binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; phosphatidylinositol 3-kinase signaling; and regulation of cellular protein metabolic process. Localizes to several cellular components, including the basolateral plasma membrane; cytosol; and endosome membrane. Implicated in malignant glioma; mammary Paget's disease; prostate cancer; renal cell carcinoma; and urinary bladder cancer. Biomarker of several diseases, including calcinosis; ductal carcinoma in situ; invasive lobular carcinoma; pre-eclampsia (multiple); and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: c-erb B2/neu protein; CD340; HER-2; HER-2/neu; HER2; herstatin; human epidermal growth factor receptor 2; metastatic lymph node gene 19 protein; MLN 19; NEU; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; proto-oncogene c-ErbB-2; proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Mus musculus (house mouse) : Erbb2 (erb-b2 receptor tyrosine kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Erbb2 (erb-b2 receptor tyrosine kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Erbb2 (erb-b2 receptor tyrosine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ERBB2 (erb-b2 receptor tyrosine kinase 2)
Canis lupus familiaris (dog) : ERBB2 (erb-b2 receptor tyrosine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Erbb2 (erb-b2 receptor tyrosine kinase 2)
Sus scrofa (pig) : ERBB2 (erb-b2 receptor tyrosine kinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381739,688,084 - 39,728,662 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371737,844,167 - 37,884,915 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361735,097,919 - 35,138,441 (+)NCBINCBI36hg18NCBI36
Build 341735,109,779 - 35,138,441NCBI
Celera1734,504,111 - 34,544,648 (+)NCBI
Cytogenetic Map17q12NCBI
HuRef1733,638,318 - 33,678,659 (+)NCBIHuRef
CHM1_11738,080,121 - 38,120,667 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

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References - curated
References - uncurated


Comparative Map Data
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miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants