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Gene: Txnrd2 (thioredoxin reductase 2) Rattus norvegicus
Symbol: Txnrd2
Name: thioredoxin reductase 2
CRRD ID: 61960
Description: Exhibits protein homodimerization activity and thioredoxin-disulfide reductase activity. Involved in response to drug; response to hyperoxia; and response to selenium ion. Localizes to several cellular components, including dendrite; mitochondrion; and neuronal cell body. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human TXNRD2 (thioredoxin reductase 2); PARTICIPATES IN pyrimidine metabolic pathway; selenoamino acid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MGC93435; thioredoxin reductase 2, mitochondrial; thioredoxin reductase TR3; Tr3; Trxr2; Trxrd2
Homo sapiens (human) : TXNRD2 (thioredoxin reductase 2)  HGNC  Alliance
Mus musculus (house mouse) : Txnrd2 (thioredoxin reductase 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Txnrd2 (thioredoxin reductase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TXNRD2 (thioredoxin reductase 2)
Canis lupus familiaris (dog) : TXNRD2 (thioredoxin reductase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Txnrd2 (thioredoxin reductase 2)
Sus scrofa (pig) : TXNRD2 (thioredoxin reductase 2)
Chlorocebus sabaeus (African green monkey) : TXNRD2 (thioredoxin reductase 2)
Heterocephalus glaber (naked mole-rat) : Txnrd2 (thioredoxin reductase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01186,667,994 - 86,716,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1186,667,997 - 86,716,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01189,762,304 - 89,809,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,513,361 - 84,561,673 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11184,553,962 - 84,602,292 (-)NCBI
Celera1181,297,140 - 81,345,203 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Txnrd2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61960
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.