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Gene: Grk1 (G protein-coupled receptor kinase 1) Rattus norvegicus
Symbol: Grk1
Name: G protein-coupled receptor kinase 1
CRRD ID: 619712
Description: Exhibits rhodopsin kinase activity. Involved in protein autophosphorylation; response to drug; and response to light stimulus. Predicted to localize to photoreceptor outer segment. Used to study congestive heart failure. Biomarker of retinal disease. Human ortholog(s) of this gene implicated in Oguchi disease-2 and night blindness. Orthologous to human GRK1 (G protein-coupled receptor kinase 1); PARTICIPATES IN visual phototransduction pathway; chemokine mediated signaling pathway; endocytosis pathway; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
Also known as: G protein-coupled receptpr kinase 1; rhodopsin kinase; rhodopsin kinase GRK1; Rhok; RK
Homo sapiens (human) : GRK1 (G protein-coupled receptor kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Grk1 (G protein-coupled receptor kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk1 (G protein-coupled receptor kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK1 (G protein-coupled receptor kinase 1)
Canis lupus familiaris (dog) : GRK1 (G protein-coupled receptor kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk1 (G protein-coupled receptor kinase 1)
Sus scrofa (pig) : GRK1 (G protein-coupled receptor kinase 1)
Chlorocebus sabaeus (African green monkey) : GRK1 (G protein-coupled receptor kinase 1)
Heterocephalus glaber (naked mole-rat) : Grk1 (G protein-coupled receptor kinase 1)
more info ...
Allele / Splice: Grk1Tn(sb-T2/Bart3)2.234Mcwi  
Genetic Models: F344-Grk1Tn(sb-T2/Bart3)2.234Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01681,153,489 - 81,165,442 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1681,153,489 - 81,165,442 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01680,641,991 - 80,657,693 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41680,979,323 - 80,991,796 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11680,979,589 - 80,992,061 (-)NCBI
Celera1673,931,302 - 73,943,259 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Grk1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619712
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.