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Gene: Lrp4 (LDL receptor related protein 4) Rattus norvegicus
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Symbol: Lrp4
Name: LDL receptor related protein 4
Description: Exhibits apolipoprotein binding activity; receptor tyrosine kinase binding activity; and scaffold protein binding activity. Involved in dendrite morphogenesis; protein heterotetramerization; and synapse organization. Localizes to several cellular components, including neuronal cell body; plasma membrane raft; and postsynaptic density. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4); PARTICIPATES IN acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (+)-schisandrin B; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: low density lipoprotein receptor-related protein 4; low-density lipoprotein receptor-related protein 4; LRP-4; Megf7; multiple epidermal growth factor-like domains 7
Orthologs:
Homo sapiens (human) : LRP4 (LDL receptor related protein 4)  HGNC  Alliance
Mus musculus (house mouse) : Lrp4 (low density lipoprotein receptor-related protein 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp4 (LDL receptor related protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP4 (LDL receptor related protein 4)
Canis lupus familiaris (dog) : LRP4 (LDL receptor related protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp4 (LDL receptor related protein 4)
Sus scrofa (pig) : LRP4 (LDL receptor related protein 4)
Chlorocebus sabaeus (African green monkey) : LRP4 (LDL receptor related protein 4)
Heterocephalus glaber (naked mole-rat) : Lrp4 (LDL receptor related protein 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0380,362,643 - 80,416,684 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,362,858 - 80,416,679 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0387,062,818 - 87,116,798 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,821,638 - 75,875,100 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,718,009 - 75,771,472 (+)NCBI
Celera376,634,746 - 76,688,537 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Lrp4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619731
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.