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Gene: Ctla4 (cytotoxic T-lymphocyte-associated protein 4) Rattus norvegicus
Symbol: Ctla4
Name: cytotoxic T-lymphocyte-associated protein 4
Description: Predicted to have signaling receptor activity. Involved in negative regulation of T cell proliferation and negative regulation of immune response. Predicted to localize to several cellular components, including clathrin-coated endocytic vesicle; external side of plasma membrane; and perinuclear region of cytoplasm. Used to study myocarditis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); carcinoma (multiple); hematologic cancer (multiple); kidney disease (multiple); and type 1 diabetes mellitus (multiple). Orthologous to human CTLA4 (cytotoxic T-lymphocyte associated protein 4); PARTICIPATES IN autoimmune thyroiditis pathway; rheumatoid arthritis pathway; T cell receptor signaling pathway; INTERACTS WITH 3H-1,2-dithiole-3-thione; ammonium chloride; bisphenol A.
Type: protein-coding
Also known as: Cd152; CD152 antigen; CTLA-4; cytotoxic T-lymphocyte protein 4; sCTLA4; soluble form; transmembrane form
Homo sapiens (human) : CTLA4 (cytotoxic T-lymphocyte associated protein 4)  HGNC  Alliance
Mus musculus (house mouse) : Ctla4 (cytotoxic T-lymphocyte-associated protein 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctla4 (cytotoxic T-lymphocyte associated protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : CTLA4 (cytotoxic T-lymphocyte associated protein 4)
Canis lupus familiaris (dog) : CTLA4 (cytotoxic T-lymphocyte associated protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ctla4 (cytotoxic T-lymphocyte associated protein 4)
Sus scrofa (pig) : CTLA4 (cytotoxic T-lymphocyte associated protein 4)
Chlorocebus sabaeus (African green monkey) : CTLA4 (cytotoxic T-lymphocyte associated protein 4)
Heterocephalus glaber (naked mole-rat) : Ctla4 (cytotoxic T-lymphocyte associated protein 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0967,699,397 - 67,706,068 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl967,699,379 - 67,706,065 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0967,509,236 - 67,515,681 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4959,495,773 - 59,501,300 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1959,642,754 - 59,648,282 (+)NCBI
Celera959,742,231 - 59,747,758 (+)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ctla4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61975
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.