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Gene: Smpd2 (sphingomyelin phosphodiesterase 2) Rattus norvegicus
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Symbol: Smpd2
Name: sphingomyelin phosphodiesterase 2
Description: Exhibits sphingomyelin phosphodiesterase activity. Involved in ceramide biosynthetic process; intracellular signal transduction; and response to mechanical stimulus. Localizes to the caveola. Orthologous to human SMPD2 (sphingomyelin phosphodiesterase 2); PARTICIPATES IN tumor necrosis factor mediated signaling pathway; sphingolipid metabolic pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: lyso-PAF-PLC; lyso-platelet-activating factor-phospholipase C; N-SMase; neutral sphingomyelinase; nSMase; sphingomyelin phosphodiesterase 2, neutral; sphingomyelin phosphodiesterase 2, neutral membrane
Orthologs:
Homo sapiens (human) : SMPD2 (sphingomyelin phosphodiesterase 2)  HGNC  Alliance
Mus musculus (house mouse) : Smpd2 (sphingomyelin phosphodiesterase 2, neutral)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smpd2 (sphingomyelin phosphodiesterase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SMPD2 (sphingomyelin phosphodiesterase 2)
Canis lupus familiaris (dog) : SMPD2 (sphingomyelin phosphodiesterase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smpd2 (sphingomyelin phosphodiesterase 2)
Sus scrofa (pig) : SMPD2 (sphingomyelin phosphodiesterase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02046,212,070 - 46,215,183 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2046,211,892 - 46,215,120 (-)Ensembl
Rnor_5.02047,904,390 - 47,907,503 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42045,448,774 - 45,451,887 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12045,471,784 - 45,474,898 (-)NCBI
Celera2054,964,269 - 54,967,382 (+)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Smpd2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619753
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.