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Gene: Fmo3 (flavin containing dimethylaniline monoxygenase 3) Rattus norvegicus
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Symbol: Fmo3
Name: flavin containing dimethylaniline monoxygenase 3
Description: Exhibits N,N-dimethylaniline monooxygenase activity; NADP binding activity; and amino acid binding activity. Involved in drug metabolic process. Localizes to the intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to human FMO3 (flavin containing dimethylaniline monoxygenase 3); PARTICIPATES IN nicotine pharmacodynamics pathway; nicotine pharmacokinetics pathway; tamoxifen pharmacodynamics pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,3,4,7,8-Pentachlorodibenzofuran; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: dimethylaniline monooxygenase [N-oxide-forming] 3; dimethylaniline oxidase 3; flavin containing monooxygenase 3; flavin-containing monooxygenase 3; FMO 3; hepatic flavin-containing monooxygenase 3; MGC93304; trimethylamine monooxygenase
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01380,837,418 - 80,856,214 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01385,732,370 - 85,750,452 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41378,659,513 - 78,678,524 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11378,673,154 - 78,692,556 (-)NCBI
Celera1375,050,485 - 75,068,979 (-)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Fmo3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619761
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.