Gene: Rapgef1 (Rap guanine nucleotide exchange factor 1) Rattus norvegicus
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Symbol: Rapgef1
Name: Rap guanine nucleotide exchange factor 1
Description: Predicted to have Rap guanyl-nucleotide exchange factor activity; involved in positive regulation of neuron projection development and regulation of signal transduction; localizes to the perinuclear region of cytoplasm, phagocytic vesicle membrane, and protein-containing complex; biomarker of anti-basement membrane glomerulonephritis and mesangial proliferative glomerulonephritis; orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: MODEL
Also known as: C3G; C3G-1; C3G-1, C3G-2; C3G-2; Grf2; Rap guanine nucleotide exchange factor (GEF) 1
Orthologs:
Homo sapiens (human) : RAPGEF1 (Rap guanine nucleotide exchange factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Rapgef1 (Rap guanine nucleotide exchange factor (GEF) 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rapgef1 (Rap guanine nucleotide exchange factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : RAPGEF1 (Rap guanine nucleotide exchange factor 1)
Canis lupus familiaris (dog) : RAPGEF1 (Rap guanine nucleotide exchange factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rapgef1 (Rap guanine nucleotide exchange factor 1)
Sus scrofa (pig) : RAPGEF1 (Rap guanine nucleotide exchange factor 1)
more info ...
Allele / Splice: Rapgef1_v2   Rapgef1_v1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.038,189,594 - 8,307,077 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0313,534,547 - 13,650,426 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.438,634,764 - 8,680,197 (+)NCBIRGSC3.4rn4RGSC3.4
Celera37,697,182 - 7,794,443 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Rapgef1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619793
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.