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Gene: Fas (Fas cell surface death receptor) Rattus norvegicus
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Symbol: Fas
Name: Fas cell surface death receptor
Description: Exhibits protease binding activity and tumor necrosis factor-activated receptor activity. Involved in several processes, including cellular response to cytokine stimulus; nervous system development; and positive regulation of apoptotic process. Localizes to several cellular components, including CD95 death-inducing signaling complex; apical dendrite; and sarcolemma. Used to study IgA glomerulonephritis; brain glioma; pre-malignant neoplasm; retinal detachment; and transient cerebral ischemia. Biomarker of several diseases, including abdominal obesity-metabolic syndrome 1; artery disease (multiple); brain ischemia (multiple); eye disease (multiple); and liver disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); cystic fibrosis; leukemia (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Orthologous to human FAS (Fas cell surface death receptor); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; intrinsic apoptotic pathway; INTERACTS WITH (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: apo-1 antigen; apoptosis-mediating surface antigen FAS; CD95 antigen; Fas (TNF receptor superfamily, member 6); Fas antigen (ATP1); Fas receptor; FASLG receptor; Tnfrsf6; tumor necrosis factor receptor superfamily member 6; Tumor necrosis factor receptor superfamily, member 6
Orthologs:
Homo sapiens (human) : FAS (Fas cell surface death receptor)  HGNC  Alliance
Mus musculus (house mouse) : Fas (Fas (TNF receptor superfamily member 6))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fas (Fas cell surface death receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : FAS (Fas cell surface death receptor)
Canis lupus familiaris (dog) : FAS (Fas cell surface death receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fas (Fas cell surface death receptor)
Sus scrofa (pig) : FAS (Fas cell surface death receptor)
Chlorocebus sabaeus (African green monkey) : FAS (Fas cell surface death receptor)
Heterocephalus glaber (naked mole-rat) : Fas (Fas cell surface death receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01252,589,785 - 252,624,790 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,589,785 - 252,624,790 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01259,812,248 - 259,846,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,259,443 - 238,274,745 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11238,423,465 - 238,438,767 (+)NCBI
Celera1228,912,823 - 228,946,152 (+)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
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Genomics

Comparative Map Data
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QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)