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Gene: Cttn (cortactin) Rattus norvegicus
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Symbol: Cttn
Name: cortactin
Description: Exhibits Arp2/3 complex binding activity and proline-rich region binding activity. Involved in several processes, including cell motility; focal adhesion assembly; and nervous system development. Localizes to several cellular components, including the clathrin-coated pit; glutamatergic synapse; and postsynaptic actin cytoskeleton. Colocalizes with several cellular components, including the actin filament; focal adhesion; and growth cone. Orthologous to human CTTN (cortactin); PARTICIPATES IN E-cadherin signaling pathway; fibroblast growth factor signaling pathway; N-cadherin signaling pathway; INTERACTS WITH (+)-schisandrin B; 2-ethoxyethanol; 2-methoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cortactin isoform B; Cttnb; MGC93456; src substrate cortactin
Orthologs:
Homo sapiens (human) : CTTN (cortactin)  HGNC  Alliance
Mus musculus (house mouse) : Cttn (cortactin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cttn (cortactin)
Pan paniscus (bonobo/pygmy chimpanzee) : CTTN (cortactin)
Canis lupus familiaris (dog) : CTTN (cortactin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cttn (cortactin)
Sus scrofa (pig) : CTTN (cortactin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01215,255,385 - 215,290,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.01217,602,698 - 217,638,196 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01222,159,088 - 222,194,579 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01224,459,485 - 224,494,974 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41204,865,768 - 204,901,221 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11205,020,464 - 205,048,384 (-)NCBI
Celera1197,159,379 - 197,194,704 (-)NCBICelera
Cytogenetic Map1q41-q42NCBI
RH 3.4 Map11561.5RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Cttn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619839
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-10-01
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.