Gene: Grk5 (G protein-coupled receptor kinase 5) Rattus norvegicus
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Symbol: Grk5
Name: G protein-coupled receptor kinase 5
Description: Predicted to have beta-adrenergic receptor kinase activity and protein serine/threonine kinase activity; involved in negative regulation of signal transduction, oligodendrocyte differentiation, and response to alkaloid; predicted to localize to the cytosol, intracellular organelle, and plasma membrane; biomarker of Parkinson's disease and hypertension; orthologous to human GRK5 (G protein-coupled receptor kinase 5); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; dopamine signaling pathway via D1 family of receptors; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: g protein-coupled receptor kinase GRK5; Gprk5; MGC93405
Orthologs:
Homo sapiens (human) : GRK5 (G protein-coupled receptor kinase 5)  HGNC  Alliance
Mus musculus (house mouse) : Grk5 (G protein-coupled receptor kinase 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grk5 (G protein-coupled receptor kinase 5)
Pan paniscus (bonobo/pygmy chimpanzee) : GRK5 (G protein-coupled receptor kinase 5)
Canis lupus familiaris (dog) : GRK5 (G protein-coupled receptor kinase 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grk5 (G protein-coupled receptor kinase 5)
Sus scrofa (pig) : GRK5 (G protein-coupled receptor kinase 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01282,265,371 - 282,467,842 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01289,603,922 - 289,802,914 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41267,495,534 - 267,693,144 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11267,706,618 - 267,904,229 (+)NCBI
Celera1255,668,943 - 255,859,242 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Grk5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61985
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.