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Gene: Grm8 (glutamate metabotropic receptor 8) Rattus norvegicus
Symbol: Grm8
Name: glutamate metabotropic receptor 8
Description: Exhibits group III metabotropic glutamate receptor activity. Involved in detection of mechanical stimulus involved in sensory perception of pain; glutamatergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Localizes to several cellular components, including GABA-ergic synapse; glutamatergic synapse; and integral component of presynaptic active zone membrane. Used to study epilepsy and visual epilepsy. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-amphetamine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: G protein-coupled receptor family C group 1 member H; G protein-coupled receptor, family C, group 1, member H; Glur8; glutamate receptor, metabotropic 8; Gprc1h; metabotropic glutamate receptor 8; metabotropic glutamate receptor subtype 8b; mGlur; Mglur8; mGluR8b
Homo sapiens (human) : GRM8 (glutamate metabotropic receptor 8)  HGNC  Alliance
Mus musculus (house mouse) : Grm8 (glutamate receptor, metabotropic 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grm8 (glutamate metabotropic receptor 8)
Pan paniscus (bonobo/pygmy chimpanzee) : GRM8 (glutamate metabotropic receptor 8)
Canis lupus familiaris (dog) : GRM8 (glutamate metabotropic receptor 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grm8 (glutamate metabotropic receptor 8)
Sus scrofa (pig) : GRM8 (glutamate metabotropic receptor 8)
Chlorocebus sabaeus (African green monkey) : GRM8 (glutamate metabotropic receptor 8)
Heterocephalus glaber (naked mole-rat) : Grm8 (glutamate metabotropic receptor 8)
more info ...
Is Marker For: Strains:   WI-Grm8em1Geh  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0454,474,344 - 55,409,526 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl454,474,136 - 55,407,922 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0454,226,315 - 55,151,544 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4453,976,781 - 54,902,331 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1454,207,857 - 55,152,488 (-)NCBI
Celera450,936,284 - 51,838,440 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Grm8
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619858
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.