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Gene: Dynll1 (dynein light chain LC8-type 1) Rattus norvegicus
Symbol: Dynll1
Name: dynein light chain LC8-type 1
Description: Exhibits several functions, including enzyme regulator activity; identical protein binding activity; and scaffold protein binding activity. Involved in negative regulation of nitric oxide biosynthetic process; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and spermatid development. Localizes to several cellular components, including axon cytoplasm; cytoplasmic dynein complex; and secretory granule. Colocalizes with mitochondrion. Used to study hypertension and impotence. Biomarker of cardiac arrest; congestive heart failure; and middle cerebral artery infarction. Orthologous to human DYNLL1 (dynein light chain LC8-type 1); PARTICIPATES IN mitochondria transport pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol.
Type: protein-coding
Also known as: 8 kDa dynein light chain; 8kD LC; 8kDLC; Dlc8; Dnclc1; dynein LC8; dynein light chain 1, cytoplasmic; dynein, cytoplasmic, light chain 1; MGC72986; Pin; protein inhibitor of neuronal nitric oxide synthase
Homo sapiens (human) : DYNLL1 (dynein light chain LC8-type 1)  HGNC  Alliance
Mus musculus (house mouse) : Dynll1 (dynein light chain LC8-type 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dynll1 (dynein light chain LC8-type 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DYNLL1 (dynein light chain LC8-type 1)
Canis lupus familiaris (dog) : DYNLL1 (dynein light chain LC8-type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dynll1 (dynein light chain LC8-type 1)
Sus scrofa (pig) : DYNLL1 (dynein light chain LC8-type 1)
Chlorocebus sabaeus (African green monkey) : DYNLL1 (dynein light chain LC8-type 1)
Heterocephalus glaber (naked mole-rat) : Dynll1 (dynein light chain LC8-type 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01247,074,200 - 47,076,573 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,074,200 - 47,076,572 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01248,867,516 - 48,869,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41242,580,542 - 42,582,915 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11242,443,929 - 42,446,302 (+)NCBI
Celera1242,933,102 - 42,935,475 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dynll1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619866
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.