Gene: Gch1 (GTP cyclohydrolase 1) Rattus norvegicus
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Symbol: Gch1
Name: GTP cyclohydrolase 1
Description: Exhibits several functions, including GTP binding activity, GTP cyclohydrolase I activity, and metal ion binding activity; involved in several processes, including dihydrobiopterin metabolic process, negative regulation of blood pressure, and protein complex oligomerization; localizes to the protein-containing complex; orthologous to human GCH1 (GTP cyclohydrolase 1); PARTICIPATES IN dopa responsive dystonia pathway; Segawa syndrome pathway; folate metabolic pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Gch; GTP cyclohydrase I; GTP cyclohydrolase I; GTP-CH-I
Orthologs:
Homo sapiens (human) : GCH1 (GTP cyclohydrolase 1)  HGNC  Alliance
Mus musculus (house mouse) : Gch1 (GTP cyclohydrolase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gch1 (GTP cyclohydrolase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GCH1 (GTP cyclohydrolase 1)
Canis lupus familiaris (dog) : GCH1 (GTP cyclohydrolase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gch1 (GTP cyclohydrolase 1)
Sus scrofa (pig) : GCH1 (GTP cyclohydrolase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01523,935,011 - 23,968,971 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01527,876,253 - 27,910,213 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41523,023,996 - 23,139,794 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11523,039,695 - 23,155,494 (-)NCBI
Celera1520,799,206 - 20,832,598 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Gch1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61992
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.