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Gene: Krt18 (keratin 18) Rattus norvegicus
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Symbol: Krt18
Name: keratin 18
CRRD ID: 619935
Description: Predicted to have scaffold protein binding activity. Involved in several processes, including cholangiocyte apoptotic process; hepatocyte differentiation; and response to fructose. Localizes to several cellular components, including external side of plasma membrane; extracellular space; and keratin filament. Biomarker of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT18 (keratin 18); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CK-18; cytokeratin-18; K18; keratin 18, type I; keratin complex 1, acidic, gene 18; keratin, type I cytoskeletal 18; keratin-18; Krt1-18; MGC109143
Orthologs:
Homo sapiens (human) : KRT18 (keratin 18)  HGNC  Alliance
Mus musculus (house mouse) : Krt18 (keratin 18)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Krt18 (keratin 18)
Pan paniscus (bonobo/pygmy chimpanzee) : KRT18 (keratin 18)
Canis lupus familiaris (dog) : KRT18 (keratin 18)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Krt18 (keratin 18)
Sus scrofa (pig) : KRT18 (keratin 18)
Chlorocebus sabaeus (African green monkey) : KRT18 (keratin 18)
Heterocephalus glaber (naked mole-rat) : Krt18 (keratin 18)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07143,629,455 - 143,633,131 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,629,455 - 143,633,131 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,425,684 - 141,429,360 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1279,988,565 - 79,989,008 (+)NCBI
Celera7129,594,039 - 129,597,715 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Krt18
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619935
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.