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Gene: Defb1 (defensin beta 1) Rattus norvegicus
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Symbol: Defb1
Name: defensin beta 1
Description: Predicted to have CCR6 chemokine receptor binding activity; double-stranded DNA binding activity; and identical protein binding activity. Involved in acute inflammatory response and response to testosterone. Predicted to localize to several cellular components, including the extracellular space; microvesicle; and sperm midpiece. Biomarker of obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and lung disease. Orthologous to human DEFB1 (defensin beta 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: BD-1; beta-defensin 1; CDK4; defensin, beta 1; rBD-1
Orthologs:
Homo sapiens (human) : DEFB1 (defensin beta 1)  HGNC  Alliance
Mus musculus (house mouse) : Defb1 (defensin beta 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102004444 (beta-defensin 1-like)
Pan paniscus (bonobo/pygmy chimpanzee) : DEFB1 (defensin beta 1)
Canis lupus familiaris (dog) : DEFB1 (defensin beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Defb1 (defensin beta 1)
Sus scrofa (pig) : DEFB1 (defensin beta 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01675,294,385 - 75,309,127 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01674,908,901 - 74,923,643 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41674,980,054 - 74,995,445 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11674,980,319 - 74,995,710 (-)NCBI
Celera1668,171,373 - 68,186,246 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Defb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619943
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.