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Gene: Nae1 (NEDD8 activating enzyme E1 subunit 1) Rattus norvegicus
Symbol: Nae1
Name: NEDD8 activating enzyme E1 subunit 1
Description: Predicted to have NEDD8 activating enzyme activity; protein heterodimerization activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including mitotic DNA replication checkpoint; neuron apoptotic process; and protein neddylation. Localizes to the early endosome and membrane raft. Biomarker of middle cerebral artery infarction. Orthologous to human NAE1 (NEDD8 activating enzyme E1 subunit 1); PARTICIPATES IN neddylation pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; Alzheimer's disease pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17alpha-ethynylestradiol; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: amyloid beta precursor protein binding protein 1; amyloid beta precursor protein-binding protein 1, 59 kDa; amyloid protein-binding protein 1; APP-binding protein 1; APP-BP1; Appbp1; LOC291815; NEDD8-activating enzyme E1 regulatory subunit; RGD1563180; similar to amyloid beta precursor protein binding protein 1
Homo sapiens (human) : NAE1 (NEDD8 activating enzyme E1 subunit 1)  HGNC  Alliance
Mus musculus (house mouse) : Nae1 (NEDD8 activating enzyme E1 subunit 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nae1 (NEDD8 activating enzyme E1 subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NAE1 (NEDD8 activating enzyme E1 subunit 1)
Canis lupus familiaris (dog) : NAE1 (NEDD8 activating enzyme E1 subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nae1 (NEDD8 activating enzyme E1 subunit 1)
Sus scrofa (pig) : NAE1 (NEDD8 activating enzyme E1 subunit 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.019653,510 - 680,378 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl19653,510 - 680,378 (+)Ensembl
Rnor_5.019646,826 - 673,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.419382,556 - 408,667 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.119382,555 - 408,667 (+)NCBI
Celera19446,357 - 467,621 (+)NCBICelera
Cytogenetic Map19p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nae1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619945
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.