Gene: Pten (phosphatase and tensin homolog) Rattus norvegicus
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Symbol: Pten
Name: phosphatase and tensin homolog
Description: Exhibits several functions, including PDZ domain binding activity, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity, and signaling receptor binding activity; involved in several processes, including cellular response to hormone stimulus, dephosphorylation, and generation of neurons; localizes to several cellular components, including the cytoplasm, dendritic spine, and intracellular membrane-bounded organelle; used to study portal hypertension and substance-related disorder; biomarker of several diseases, including fatty liver disease, fetal alcohol spectrum disorder, glucose metabolism disease (multiple), renal cell carcinoma, and retinitis pigmentosa; orthologous to human PTEN (phosphatase and tensin homolog); PARTICIPATES IN altered phosphatidylinositol 3-kinase signaling pathway; altered phosphatidylinositol 3-kinase-Akt signaling pathway; endometrial cancer pathway; INTERACTS WITH (+)-pilocarpine; (R)-noradrenaline; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Mmac; MMAC1; mutated in multiple advanced cancers 1; phosphatase and tensin homolog (mutated in multiple advanced cancers 1); phosphatase and tensin homolog deleted on chromosome ten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase and tensin-like protein; TEP1
Orthologs:
Homo sapiens (human) : PTEN (phosphatase and tensin homolog)  HGNC  Alliance
Mus musculus (house mouse) : Pten (phosphatase and tensin homolog)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pten (phosphatase and tensin homolog)
Pan paniscus (bonobo/pygmy chimpanzee) : PTEN (phosphatase and tensin homolog)
Canis lupus familiaris (dog) : PTEN (phosphatase and tensin homolog)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pten (phosphatase and tensin homolog)
Sus scrofa (pig) : PTEN (phosphatase and tensin homolog)
more info ...
Allele / Splice: Ptenem1Sage  
Genetic Models: SD-Ptenem1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01251,421,814 - 251,487,634 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01258,651,829 - 258,717,009 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,771,027 - 236,837,261 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11236,935,049 - 237,001,284 (+)NCBI
Celera1227,746,622 - 227,812,108 (+)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations