Gene: F2 (coagulation factor II) Rattus norvegicus
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Symbol: F2
Name: coagulation factor II
Description: Predicted to have several functions, including enzyme activator activity, heparin binding activity, and lipopolysaccharide binding activity; involved in several processes, including blood coagulation, cellular response to mechanical stimulus, and positive regulation of blood coagulation; localizes to the collagen-containing extracellular matrix and extracellular space; predicted to colocalize with the external side of plasma membrane; used to study several diseases, including atherosclerosis, end stage renal failure, hyperhomocysteinemia, malignant glioma, and thrombophilia (multiple); biomarker of bacterial pneumonia, brain edema, and thrombosis; orthologous to human F2 (coagulation factor II, thrombin); PARTICIPATES IN coagulation cascade pathway; acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: coagulation factor 2; prothrombin; thrombin
Orthologs:
Homo sapiens (human) : F2 (coagulation factor II, thrombin)  HGNC  Alliance
Mus musculus (house mouse) : F2 (coagulation factor II)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F2 (coagulation factor II, thrombin)
Pan paniscus (bonobo/pygmy chimpanzee) : F2 (coagulation factor II, thrombin)
Canis lupus familiaris (dog) : F2 (coagulation factor II, thrombin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F2 (coagulation factor II, thrombin)
Sus scrofa (pig) : F2 (coagulation factor II, thrombin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0380,529,468 - 80,542,993 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0387,228,703 - 87,242,228 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4376,005,318 - 76,018,603 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,901,694 - 75,914,982 (-)NCBI
Celera376,801,000 - 76,814,280 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on F2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 61996
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.