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Gene: C1s (complement C1s) Rattus norvegicus
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Symbol: C1s
Name: complement C1s
Description: Predicted to have identical protein binding activity and serine-type endopeptidase activity. Involved in glial cell differentiation and response to cAMP. Localizes to the extracellular region. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome. Orthologous to human C1S (complement C1s); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C1 esterase; complement C1s subcomponent; complement component 1 subcomponent s; complement component 1, s subcomponent; r-gsp
Orthologs:
Homo sapiens (human) : C1S (complement C1s)  HGNC  Alliance
Mus musculus (house mouse) : C1s2 (complement component 1, s subcomponent 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : C1s (complement C1s)
Pan paniscus (bonobo/pygmy chimpanzee) : C1S (complement C1s)
Canis lupus familiaris (dog) : C1S (complement C1s)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : C1s (complement C1s)
Sus scrofa (pig) : C1S (complement C1s)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04157,143,592 - 157,155,592 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04224,162,096 - 224,174,096 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44160,736,133 - 160,748,133 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14160,981,068 - 160,993,073 (-)NCBI
Celera4146,169,963 - 146,181,341 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on C1s
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619983
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.