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Gene: Atp5f1a (ATP synthase F1 subunit alpha) Rattus norvegicus
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Symbol: Atp5f1a
Name: ATP synthase F1 subunit alpha
Description: Exhibits ADP binding activity; ATP binding activity; and protease binding activity. Contributes to ATPase activity. Involved in several processes, including aging; cellular response to dexamethasone stimulus; and cellular response to nitric oxide. Localizes to the cell surface; intracellular membrane-bounded organelle; and membrane raft. Predicted to colocalize with the COP9 signalosome. Used to study nonalcoholic fatty liver disease and pulmonary hypertension. Biomarker of Alzheimer's disease and hypertension. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency and mitochondrial complex V (ATP synthase) deficiency nuclear type 4. Orthologous to human ATP5F1A (ATP synthase F1 subunit alpha); PARTICIPATES IN electron transport chain pathway; Alzheimer's disease pathway; Huntington's disease pathway; INTERACTS WITH (R)-adrenaline; (S)-nicotine; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP synthase subunit alpha, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1; atp synthase, h+ transporting, mitochondrial f1 complex, alpha subunit, isoform 1.; Atp5a1; mitochondrial H+-ATP synthase alpha subunit
Orthologs:
Homo sapiens (human) : ATP5F1A (ATP synthase F1 subunit alpha)  HGNC  Alliance
Mus musculus (house mouse) : Atp5a1 (ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp5f1a (ATP synthase F1 subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP5F1A (ATP synthase F1 subunit alpha)
Canis lupus familiaris (dog) : ATP5F1A (ATP synthase F1 subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp5f1a (ATP synthase F1 subunit alpha)
Sus scrofa (pig) : ATP5F1A (ATP synthase F1 subunit alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01874,156,553 - 74,164,490 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01873,830,604 - 73,838,477 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41874,735,267 - 74,743,088 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11874,808,539 - 74,816,361 (+)NCBI
Celera1869,811,132 - 69,819,068 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Atp5f1a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 619993
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.