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Gene: Chrm2 (cholinergic receptor, muscarinic 2) Rattus norvegicus
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Symbol: Chrm2
Name: cholinergic receptor, muscarinic 2
Description: Exhibits G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway and regulation of smooth muscle contraction. Localizes to several cellular components, including the glutamatergic synapse; integral component of synaptic membrane; and neuron projection. Biomarker of mental depression. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; asthma; bipolar disorder; heroin dependence; and major depressive disorder. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 7TM receptor; Acm2; cholinergic receptor, muscarinic 2, cardiac; LOC100912433; M2 muscarinic acetylcholine receptor; muscarinic acetylcholine receptor M2; muscarinic acetylcholine receptor M2-like; muscarinic receptor m2
Orthologs:
Homo sapiens (human) : CHRM2 (cholinergic receptor muscarinic 2)  HGNC  Alliance
Mus musculus (house mouse) : Chrm2 (cholinergic receptor, muscarinic 2, cardiac)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Chrm2 (cholinergic receptor muscarinic 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CHRM2 (cholinergic receptor muscarinic 2)
Canis lupus familiaris (dog) : CHRM2 (cholinergic receptor muscarinic 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Chrm2 (cholinergic receptor muscarinic 2)
Sus scrofa (pig) : CHRM2 (cholinergic receptor muscarinic 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0464,089,028 - 64,091,090 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0463,799,489 - 63,801,551 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4463,911,292 - 63,913,354 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1464,190,944 - 64,191,339 (+)NCBI
Celera460,177,151 - 60,179,213 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Chrm2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620023
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.