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Gene: Nr4a1 (nuclear receptor subfamily 4, group A, member 1) Rattus norvegicus
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Symbol: Nr4a1
Name: nuclear receptor subfamily 4, group A, member 1
CRRD ID: 620029
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; glucocorticoid receptor binding activity; and protein heterodimerization activity. Involved in several processes, including regulation of type B pancreatic cell proliferation; response to electrical stimulus; and response to lipopolysaccharide. Localizes to nucleus. Used to study chronic kidney disease. Biomarker of mesangial proliferative glomerulonephritis. Orthologous to human NR4A1 (nuclear receptor subfamily 4 group A member 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: HMR; immediate early gene transcription factor NGFI-B; nerve growth factor induced protein I-B; nerve growth factor-induced protein I-B; Ngfi-b; nuclear receptor subfamily 4 group A member 1; Nur77; Orphan nuclear receptor HMR
Orthologs:
Homo sapiens (human) : NR4A1 (nuclear receptor subfamily 4 group A member 1)  HGNC  Alliance
Mus musculus (house mouse) : Nr4a1 (nuclear receptor subfamily 4, group A, member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr4a1 (nuclear receptor subfamily 4 group A member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NR4A1 (nuclear receptor subfamily 4 group A member 1)
Canis lupus familiaris (dog) : NR4A1 (nuclear receptor subfamily 4 group A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr4a1 (nuclear receptor subfamily 4 group A member 1)
Chlorocebus sabaeus (African green monkey) : NR4A1 (nuclear receptor subfamily 4 group A member 1)
Heterocephalus glaber (naked mole-rat) : Nr4a1 (nuclear receptor subfamily 4 group A member 1)
more info ...
Allele / Splice: Nr4a1m1Mcwi  
Genetic Models: FHH-Nr4a1m1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.07142,899,358 - 142,920,216 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,905,758 - 142,920,216 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07140,700,242 - 140,721,073 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,012,807 - 140,020,590 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.17140,089,243 - 140,097,024 (+)NCBI
Celera7128,846,928 - 128,854,640 (+)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
Experimental Data Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nr4a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620029
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-10-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.