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Gene: Sphk1 (sphingosine kinase 1) Rattus norvegicus
Symbol: Sphk1
Name: sphingosine kinase 1
Description: Exhibits D-erythro-sphingosine kinase activity. Involved in several processes, including cyclooxygenase pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including axon; cytosol; and synaptic vesicle. Biomarker of adenocarcinoma and malignant glioma. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SPHK1 (sphingosine kinase 1); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acetyltransferase SPHK1; SK 1; SPK 1
Homo sapiens (human) : SPHK1 (sphingosine kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Sphk1 (sphingosine kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sphk1 (sphingosine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPHK1 (sphingosine kinase 1)
Canis lupus familiaris (dog) : SPHK1 (sphingosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sphk1 (sphingosine kinase 1)
Sus scrofa (pig) : SPHK1 (sphingosine kinase 1)
Chlorocebus sabaeus (African green monkey) : SPHK1 (sphingosine kinase 1)
Heterocephalus glaber (naked mole-rat) : Sphk1 (sphingosine kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.010105,498,728 - 105,504,401 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,498,728 - 105,504,393 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,162,314 - 105,167,987 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,641,509 - 106,645,579 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110106,656,012 - 106,660,081 (+)NCBI
Celera10100,330,875 - 100,336,542 (+)NCBICelera
Cytogenetic Map10q32.1-q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Sphk1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620048
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.