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Gene: Sphk1 (sphingosine kinase 1) Rattus norvegicus
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Symbol: Sphk1
Name: sphingosine kinase 1
Description: Exhibits D-erythro-sphingosine kinase activity. Involved in several processes, including cyclooxygenase pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including axon; cytosol; and synaptic vesicle. Biomarker of adenocarcinoma and malignant glioma. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SPHK1 (sphingosine kinase 1); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acetyltransferase SPHK1; SK 1; SPK 1
Orthologs:
Homo sapiens (human) : SPHK1 (sphingosine kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Sphk1 (sphingosine kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sphk1 (sphingosine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPHK1 (sphingosine kinase 1)
Canis lupus familiaris (dog) : SPHK1 (sphingosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sphk1 (sphingosine kinase 1)
Sus scrofa (pig) : SPHK1 (sphingosine kinase 1)
Chlorocebus sabaeus (African green monkey) : SPHK1 (sphingosine kinase 1)
Heterocephalus glaber (naked mole-rat) : Sphk1 (sphingosine kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.010105,498,728 - 105,504,401 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,498,728 - 105,504,393 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,162,314 - 105,167,987 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,641,509 - 106,645,579 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110106,656,012 - 106,660,081 (+)NCBI
Celera10100,330,875 - 100,336,542 (+)NCBICelera
Cytogenetic Map10q32.1-q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Sphk1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620048
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.