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Gene: Smc3 (structural maintenance of chromosomes 3) Rattus norvegicus
Symbol: Smc3
Name: structural maintenance of chromosomes 3
Description: Predicted to have several functions, including beta-tubulin binding activity; dynein complex binding activity; and mediator complex binding activity. Predicted to be involved in several processes, including regulation of DNA replication; regulation of mitotic spindle assembly; and sister chromatid cohesion. Localizes to the basement membrane. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3. Orthologous to human SMC3 (structural maintenance of chromosomes 3); PARTICIPATES IN cell cycle pathway, mitotic; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: bamacan; basement membrane chondroitin sulfate proteoglycan; basement membrane-associated chondroitin proteoglycan; chondroitin sulfate proteoglycan 6; chromosome segregation protein SmcD; Cspg6; SMC protein 3; SMC-3; structural maintenace of chromosomes 3; structural maintenance of chromosomes protein 3
Homo sapiens (human) : SMC3 (structural maintenance of chromosomes 3)  HGNC  Alliance
Mus musculus (house mouse) : Smc3 (structural maintenance of chromosomes 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smc3 (structural maintenance of chromosomes 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SMC3 (structural maintenance of chromosomes 3)
Canis lupus familiaris (dog) : SMC3 (structural maintenance of chromosomes 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smc3 (structural maintenance of chromosomes 3)
Sus scrofa (pig) : SMC3 (structural maintenance of chromosomes 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01274,310,120 - 274,352,856 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1274,309,758 - 274,352,854 (+)Ensembl
Rnor_5.01281,719,796 - 281,762,532 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41259,822,480 - 259,865,602 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11260,033,557 - 260,076,645 (+)NCBI
Celera1248,320,880 - 248,363,620 (+)NCBICelera
Cytogenetic Map1q55NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Smc3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 62006
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.