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Gene: Ilk (integrin-linked kinase) Rattus norvegicus
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Symbol: Ilk
Name: integrin-linked kinase
Description: Exhibits SH3 domain binding activity; integrin binding activity; and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of apoptotic process; nervous system development; and regulation of protein kinase activity. Localizes to several cellular components, including costamere; dendritic shaft; and focal adhesion. Colocalizes with stress fiber. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ILK (integrin linked kinase); PARTICIPATES IN integrin mediated signaling pathway; altered integrin mediated signaling pathway; pancreatic cancer pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 2-nitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: integrin linked kinase; integrin-linked protein kinase
Orthologs:
Homo sapiens (human) : ILK (integrin linked kinase)  HGNC  Alliance
Mus musculus (house mouse) : Ilk (integrin linked kinase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ilk (integrin linked kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : ILK (integrin linked kinase)
Canis lupus familiaris (dog) : ILK (integrin linked kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ilk (integrin linked kinase)
Sus scrofa (pig) : ILK (integrin linked kinase)
Chlorocebus sabaeus (African green monkey) : ILK (integrin linked kinase)
Heterocephalus glaber (naked mole-rat) : Ilk (integrin linked kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01170,578,941 - 170,585,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,578,889 - 170,585,189 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,584,793 - 177,591,044 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,481,299 - 163,487,550 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11163,576,775 - 163,583,027 (+)NCBI
Celera1158,020,986 - 158,027,237 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ilk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620063
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.