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Gene: Gdf5 (growth differentiation factor 5) Rattus norvegicus
Symbol: Gdf5
Name: growth differentiation factor 5
Description: Exhibits signaling receptor binding activity. Involved in several processes, including negative regulation of neuron apoptotic process; ossification involved in bone remodeling; and positive regulation of neuron differentiation. Predicted to localize to extracellular space. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; bone development disease (multiple); osteoarthritis; and proximal symphalangism. Orthologous to human GDF5 (growth differentiation factor 5); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; C60 fullerene.
Type: protein-coding
RefSeq Status: MODEL
Also known as: cartilage-derived morphogenetic protein 1; Cdmp1; growth/differentiation factor 5
Homo sapiens (human) : GDF5 (growth differentiation factor 5)  HGNC  Alliance
Mus musculus (house mouse) : Gdf5 (growth differentiation factor 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gdf5 (growth differentiation factor 5)
Pan paniscus (bonobo/pygmy chimpanzee) : GDF5 (growth differentiation factor 5)
Canis lupus familiaris (dog) : GDF5 (growth differentiation factor 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gdf5 (growth differentiation factor 5)
Sus scrofa (pig) : GDF5 (growth differentiation factor 5)
Chlorocebus sabaeus (African green monkey) : GDF5 (growth differentiation factor 5)
Heterocephalus glaber (naked mole-rat) : Gdf5 (growth differentiation factor 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03151,482,672 - 151,487,129 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3151,483,249 - 151,486,693 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03157,849,749 - 157,853,231 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera3143,176,803 - 143,181,254 (-)NCBICelera
Cytogenetic Map3q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Gdf5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620102
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.