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Gene: Numb (NUMB, endocytic adaptor protein) Rattus norvegicus
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Symbol: Numb
Name: NUMB, endocytic adaptor protein
Description: Predicted to have alpha-catenin binding activity; beta-catenin binding activity; and cadherin binding activity. Involved in positive regulation of dendrite morphogenesis and regulation of postsynaptic specialization assembly. Localizes to the apical part of cell; glutamatergic synapse; and postsynaptic density. Orthologous to human NUMB (NUMB endocytic adaptor protein); PARTICIPATES IN altered Notch signaling pathway; altered Notch signaling pathway involving the macromolecules modifying the main players; Notch signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC188364; numb gene homolog; numb gene homolog (Drosophila); numb homolog; numb homolog (Drosophila)
Orthologs:
Homo sapiens (human) : NUMB (NUMB endocytic adaptor protein)  HGNC  Alliance
Mus musculus (house mouse) : Numb (NUMB endocytic adaptor protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Numb (NUMB endocytic adaptor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : NUMB (NUMB endocytic adaptor protein)
Canis lupus familiaris (dog) : NUMB (NUMB endocytic adaptor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Numb (NUMB endocytic adaptor protein)
Sus scrofa (pig) : NUMB (NUMB endocytic adaptor protein)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06107,279,917 - 107,325,345 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06118,218,526 - 118,262,951 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46107,838,216 - 107,882,302 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16107,842,337 - 107,845,590 (-)NCBI
Celera6101,261,488 - 101,306,906 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Numb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620107
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.