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Gene: Sh2b1 (SH2B adaptor protein 1) Rattus norvegicus
Symbol: Sh2b1
Name: SH2B adaptor protein 1
Description: Predicted to have transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in several processes, including lamellipodium assembly; positive regulation of mitotic nuclear division; and regulation of DNA biosynthetic process. Predicted to localize to the plasma membrane. Orthologous to human SH2B1 (SH2B adaptor protein 1); PARTICIPATES IN leptin system pathway; neurotrophic factor signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: fceRI gamma-chain-interacting protein SH2-B; SH2 domain-containing protein 1B; Sh2-b; SH2-B PH domain containing signaling mediator 1; SH2-B PH domain-containing signaling mediator 1; Sh2b; SH2B adapter protein 1; Sh2bpsm1
Homo sapiens (human) : SH2B1 (SH2B adaptor protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Sh2b1 (SH2B adaptor protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2b1 (SH2B adaptor protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SH2B1 (SH2B adaptor protein 1)
Canis lupus familiaris (dog) : SH2B1 (SH2B adaptor protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2b1 (SH2B adaptor protein 1)
Sus scrofa (pig) : SH2B1 (SH2B adaptor protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01197,878,839 - 197,888,223 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01204,857,973 - 204,867,302 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1178,707,989 - 178,715,895 (-)NCBICelera
Cytogenetic Map1q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Sh2b1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620132
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.