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Gene: Slc8a2 (solute carrier family 8 member A2) Rattus norvegicus
Symbol: Slc8a2
Name: solute carrier family 8 member A2
Description: Exhibits calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration and calcium:sodium antiporter activity. Involved in inorganic cation transmembrane transport; response to vitamin D; and telencephalon development. Localizes to several cellular components, including dendritic spine; integral component of mitochondrial membrane; and integral component of postsynaptic membrane. Biomarker of brain ischemia and status epilepticus. Orthologous to human SLC8A2 (solute carrier family 8 member A2); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
Also known as: na(+)/Ca(2+)-exchange protein 2; Ncx2; sodium/calcium exchanger 2; solute carrier family 8 (sodium/calcium exchanger), member 2; solute carrier family 8 member 2
Homo sapiens (human) : SLC8A2 (solute carrier family 8 member A2)  HGNC  Alliance
Mus musculus (house mouse) : Slc8a2 (solute carrier family 8 (sodium/calcium exchanger), member 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc8a2 (solute carrier family 8 member A2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC8A2 (solute carrier family 8 member A2)
Canis lupus familiaris (dog) : SLC8A2 (solute carrier family 8 member A2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc8a2 (solute carrier family 8 member A2)
Sus scrofa (pig) : SLC8A2 (solute carrier family 8 member A2)
Chlorocebus sabaeus (African green monkey) : SLC8A2 (solute carrier family 8 member A2)
Heterocephalus glaber (naked mole-rat) : Slc8a2 (solute carrier family 8 member A2)
more info ...
Allele / Splice: Slc8a2m1Mcwi  
Genetic Models: FHH-Slc8a2m1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0178,029,555 - 78,054,042 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,025,995 - 78,060,111 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0179,296,259 - 79,320,746 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,473,938 - 76,498,624 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1176,552,048 - 76,576,735 (+)NCBI
Celera171,312,731 - 71,337,222 (+)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Slc8a2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620194
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.