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Gene: Creb1 (cAMP responsive element binding protein 1) Rattus norvegicus
Symbol: Creb1
Name: cAMP responsive element binding protein 1
Description: Exhibits several functions, including Hsp70 protein binding activity; RNA polymerase II transcription coactivator binding activity; and arrestin family protein binding activity. Involved in several processes, including cellular response to growth factor stimulus; learning or memory; and regulation of gene expression. Localizes to several cellular components, including axon; mitochondrial matrix; and nuclear chromatin. Used to study transient cerebral ischemia. Biomarker of Huntington's disease; brain ischemia; and sciatic neuropathy. Orthologous to human CREB1 (cAMP responsive element binding protein 1); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; adenosine signaling pathway; follicle-stimulating hormone signaling pathway; INTERACTS WITH (R)-adrenaline; (R)-Salsolinol; (S)-3,5-dihydroxyphenylglycine.
Type: protein-coding
Also known as: cAMP response element binding protein 1; cAMP-responsive element-binding protein 1; Creb; CREB-1; cyclic AMP-responsive element-binding protein 1; Y protein
Homo sapiens (human) : CREB1 (cAMP responsive element binding protein 1)  HGNC  Alliance
Mus musculus (house mouse) : Creb1 (cAMP responsive element binding protein 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Creb1 (cAMP responsive element binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CREB1 (cAMP responsive element binding protein 1)
Canis lupus familiaris (dog) : CREB1 (cAMP responsive element binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Creb1 (cAMP responsive element binding protein 1)
Sus scrofa (pig) : CREB1 (cAMP responsive element binding protein 1)
Chlorocebus sabaeus (African green monkey) : CREB1 (cAMP responsive element binding protein 1)
Heterocephalus glaber (naked mole-rat) : Creb1 (cAMP responsive element binding protein 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0971,229,753 - 71,298,994 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl971,230,108 - 71,293,435 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0971,277,171 - 71,346,198 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4963,170,785 - 63,234,727 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1963,317,766 - 63,381,709 (+)NCBI
Celera963,310,784 - 63,374,139 (+)NCBICelera
Cytogenetic Map9q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Creb1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620218
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.