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Gene: Lef1 (lymphoid enhancer binding factor 1) Rattus norvegicus
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Symbol: Lef1
Name: lymphoid enhancer binding factor 1
Description: Predicted to have several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and protein domain specific binding activity. Involved in several processes, including animal organ development; odontoblast differentiation; and response to lithium ion. Localizes to nucleus. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human LEF1 (lymphoid enhancer binding factor 1); PARTICIPATES IN Wnt signaling, canonical pathway; acute myeloid leukemia pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1,3-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LEF-1; lymphoid enhancer binding factor 1 short isoform; lymphoid enhancer-binding factor 1
Orthologs:
Homo sapiens (human) : LEF1 (lymphoid enhancer binding factor 1)  HGNC  Alliance
Mus musculus (house mouse) : Lef1 (lymphoid enhancer binding factor 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lef1 (lymphoid enhancer binding factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : LEF1 (lymphoid enhancer binding factor 1)
Canis lupus familiaris (dog) : LEF1 (lymphoid enhancer binding factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lef1 (lymphoid enhancer binding factor 1)
Sus scrofa (pig) : LEF1 (lymphoid enhancer binding factor 1)
Chlorocebus sabaeus (African green monkey) : LEF1 (lymphoid enhancer binding factor 1)
Heterocephalus glaber (naked mole-rat) : Lef1 (lymphoid enhancer binding factor 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02236,232,115 - 236,345,061 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2236,233,239 - 236,345,056 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02254,781,171 - 254,893,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42228,550,263 - 228,673,131 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12228,537,002 - 228,659,871 (+)NCBI
Celera2211,924,784 - 212,018,812 (+)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Lef1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620241
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.