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Gene: P2rx3 (purinergic receptor P2X 3) Rattus norvegicus
Symbol: P2rx3
Name: purinergic receptor P2X 3
CRRD ID: 620253
Description: Exhibits several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and purinergic nucleotide receptor activity. Involved in several processes, including behavioral response to formalin induced pain; neuronal action potential; and positive regulation of sensory perception of pain. Localizes to several cellular components, including dendritic spine; integral component of presynaptic membrane; and rough endoplasmic reticulum. Orthologous to human P2RX3 (purinergic receptor P2X 3); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP receptor; P2X purinoceptor 3; P2X3; purinergic receptor P2X ligand-gated ion channel, 3; purinergic receptor P2X, ligand-gated ion channel, 3
Homo sapiens (human) : P2RX3 (purinergic receptor P2X 3)  HGNC  Alliance
Mus musculus (house mouse) : P2rx3 (purinergic receptor P2X, ligand-gated ion channel, 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P2rx3 (purinergic receptor P2X 3)
Pan paniscus (bonobo/pygmy chimpanzee) : P2RX3 (purinergic receptor P2X 3)
Canis lupus familiaris (dog) : P2RX3 (purinergic receptor P2X 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P2rx3 (purinergic receptor P2X 3)
Sus scrofa (pig) : P2RX3 (purinergic receptor P2X 3)
Chlorocebus sabaeus (African green monkey) : P2RX3 (purinergic receptor P2X 3)
Heterocephalus glaber (naked mole-rat) : P2rx3 (purinergic receptor P2X 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0372,403,992 - 72,447,801 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,403,993 - 72,447,801 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,914,029 - 78,958,459 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4368,228,045 - 68,270,751 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1368,124,416 - 68,167,123 (-)NCBI
Celera369,431,850 - 69,475,670 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on P2rx3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620253
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.