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Gene: Clock (clock circadian regulator) Rattus norvegicus
Symbol: Clock
Name: clock circadian regulator
Description: Predicted to have DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and histone acetyltransferase activity. Involved in several processes, including entrainment of circadian clock; female pregnancy; and positive regulation of transcription, DNA-templated. Localizes to nucleolus; perichromatin fibrils; and rough endoplasmic reticulum. Biomarker of cholestasis and hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human CLOCK (clock circadian regulator); INTERACTS WITH 4,4'-diaminodiphenylmethane; ammonium chloride; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: circadian locomoter output cycles kaput; circadian locomoter output cycles protein kaput; clock homolog (mouse); rCLOCK
Homo sapiens (human) : CLOCK (clock circadian regulator)  HGNC  Alliance
Mus musculus (house mouse) : Clock (circadian locomotor output cycles kaput)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clock (clock circadian regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : CLOCK (clock circadian regulator)
Canis lupus familiaris (dog) : CLOCK (clock circadian regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clock (clock circadian regulator)
Sus scrofa (pig) : CLOCK (clock circadian regulator)
Chlorocebus sabaeus (African green monkey) : CLOCK (clock circadian regulator)
Heterocephalus glaber (naked mole-rat) : Clock (clock circadian regulator)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01434,418,226 - 34,502,218 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1434,446,616 - 34,502,218 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01434,233,721 - 34,289,468 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41434,218,472 - 34,258,054 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11434,218,471 - 34,258,054 (+)NCBI
Celera1431,247,422 - 31,293,707 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Clock
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620271
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.