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Gene: Btc (betacellulin) Rattus norvegicus
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Symbol: Btc
Name: betacellulin
Description: Exhibits epidermal growth factor receptor binding activity and growth factor activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of fibroblast proliferation; and positive regulation of urine volume. Predicted to localize to extracellular space. Biomarker of otitis media. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human BTC (betacellulin); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: probetacellulin
Orthologs:
Homo sapiens (human) : BTC (betacellulin)  HGNC  Alliance
Mus musculus (house mouse) : Btc (betacellulin, epidermal growth factor family member)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Btc (betacellulin)
Pan paniscus (bonobo/pygmy chimpanzee) : BTC (betacellulin)
Canis lupus familiaris (dog) : BTC (betacellulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Btc (betacellulin)
Sus scrofa (pig) : BTC (betacellulin)
Chlorocebus sabaeus (African green monkey) : BTC (betacellulin)
Heterocephalus glaber (naked mole-rat) : Btc (betacellulin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01418,231,854 - 18,270,621 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,231,860 - 18,272,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,121,506 - 18,182,171 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,194,470 - 18,235,228 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11418,214,004 - 18,235,228 (+)NCBI
Celera1416,107,460 - 16,127,465 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Btc
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620275
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.