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Gene: Calr (calreticulin) Rattus norvegicus
Symbol: Calr
Name: calreticulin
Description: Exhibits several functions, including mRNA binding activity; metal ion binding activity; and peptide binding activity. Involved in several processes, including cellular response to lithium ion; response to estradiol; and response to testosterone. Localizes to several cellular components, including acrosomal vesicle; endoplasmic reticulum; and perinuclear region of cytoplasm. Biomarker of vitamin B12 deficiency. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; sideroblastic anemia; and thrombocytosis. Orthologous to human CALR (calreticulin); PARTICIPATES IN calcium/calcium-mediated signaling pathway; antigen processing and presentation pathway; Chagas disease pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CABP3; CALBP; calcium-binding protein 3; calregulin; CRP55; endoplasmic reticulum resident protein 60; ERp60; HACBP
Homo sapiens (human) : CALR (calreticulin)  HGNC  Alliance
Mus musculus (house mouse) : Calr (calreticulin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Calr (calreticulin)
Pan paniscus (bonobo/pygmy chimpanzee) : CALR (calreticulin)
Canis lupus familiaris (dog) : CALR (calreticulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Calr (calreticulin)
Sus scrofa (pig) : CALR (calreticulin)
Chlorocebus sabaeus (African green monkey) : CALR (calreticulin)
Heterocephalus glaber (naked mole-rat) : Calr (calreticulin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01925,956,771 - 25,961,666 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1925,956,771 - 25,961,666 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,932,394 - 36,937,289 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,964,775 - 24,969,670 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11924,969,631 - 24,974,494 (+)NCBI
Celera1922,865,445 - 22,870,340 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Calr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620288
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.