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Gene: Ece1 (endothelin converting enzyme 1) Rattus norvegicus
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Symbol: Ece1
Name: endothelin converting enzyme 1
Description: Exhibits protein homodimerization activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of receptor recycling; and regulation of signal transduction. Localizes to the early endosome; external side of plasma membrane; and secretory granule. Used to study acute kidney failure; congestive heart failure; hyperhomocysteinemia; hypertension; and pulmonary hypertension. Biomarker of acute kidney failure; congestive heart failure; hypertension; nephrotic syndrome; and renal fibrosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; essential hypertension; and hypertension. Orthologous to human ECE1 (endothelin converting enzyme 1); PARTICIPATES IN endothelin signaling pathway; INTERACTS WITH (RS)-amphetamine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Ece; ECE-1; Endothelin-converting enzyme; endothelin-converting enzyme 1
Orthologs:
Homo sapiens (human) : ECE1 (endothelin converting enzyme 1)  HGNC  Alliance
Mus musculus (house mouse) : Ece1 (endothelin converting enzyme 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ece1 (endothelin converting enzyme 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ECE1 (endothelin converting enzyme 1)
Canis lupus familiaris (dog) : ECE1 (endothelin converting enzyme 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ece1 (endothelin converting enzyme 1)
Sus scrofa (pig) : ECE1 (endothelin converting enzyme 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.05156,215,469 - 156,318,652 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.05159,968,604 - 160,075,347 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,635,656 - 156,735,783 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.15156,645,659 - 156,747,472 (+)NCBI
Celera5148,472,086 - 148,571,980 (+)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Ece1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620293
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.