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Gene: Abcg8 (ATP binding cassette subfamily G member 8) Rattus norvegicus
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Symbol: Abcg8
Name: ATP binding cassette subfamily G member 8
Description: Predicted to contribute to ATP binding activity; ATPase activity; and cholesterol transfer activity. Involved in response to drug and response to nutrient. Predicted to localize to several cellular components, including the ATP-binding activity cassette (ABC) transporter complex; apical plasma membrane; and integral component of plasma membrane. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; gallbladder disease; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP-binding cassette sub-family G member 8; ATP-binding cassette, sub-family G (WHITE), member 8; ATP-binding cassette, subfamily G (WHITE), member 8; sterolin 2; sterolin-2
Orthologs:
Homo sapiens (human) : ABCG8 (ATP binding cassette subfamily G member 8)  HGNC  Alliance
Mus musculus (house mouse) : Abcg8 (ATP binding cassette subfamily G member 8)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Abcg8 (ATP binding cassette subfamily G member 8)
Pan paniscus (bonobo/pygmy chimpanzee) : ABCG8 (ATP binding cassette subfamily G member 8)
Canis lupus familiaris (dog) : ABCG8 (ATP binding cassette subfamily G member 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abcg8 (ATP binding cassette subfamily G member 8)
Sus scrofa (pig) : ABCG8 (ATP binding cassette subfamily G member 8)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.067,961,413 - 7,980,708 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl67,961,413 - 7,980,708 (+)Ensembl
Rnor_5.067,897,005 - 7,916,593 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,064,631 - 8,083,271 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.168,064,630 - 8,083,271 (+)NCBI
Celera69,667,270 - 9,686,500 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Abcg8
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620300
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.