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Gene: Ryr2 (ryanodine receptor 2) Rattus norvegicus
Symbol: Ryr2
Name: ryanodine receptor 2
Description: Exhibits calcium-induced calcium release activity; ryanodine-sensitive calcium-release channel activity; and scaffold protein binding activity. Involved in several processes, including metal ion transport; negative regulation of cytosolic calcium ion concentration; and response to magnesium ion. Localizes to several cellular components, including A band; extrinsic component of cytoplasmic side of plasma membrane; and sarcolemma. Colocalizes with Z disc. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 2; and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (S)-nicotine; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 17beta-estradiol.
Type: protein-coding
Also known as: cardiac muscle ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel; cardiac-type ryaodine receptor; LOC689560; ryanodine receptor 2, cardiac; ryanodine receptor type II; RyR; RYR-2; similar to ryanodine receptor 2, cardiac; type 2 ryanodine receptor
Homo sapiens (human) : RYR2 (ryanodine receptor 2)  HGNC  Alliance
Mus musculus (house mouse) : Ryr2 (ryanodine receptor 2, cardiac)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ryr2 (ryanodine receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RYR2 (ryanodine receptor 2)
Canis lupus familiaris (dog) : RYR2 (ryanodine receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ryr2 (ryanodine receptor 2)
Sus scrofa (pig) : RYR2 (ryanodine receptor 2)
Chlorocebus sabaeus (African green monkey) : RYR2 (ryanodine receptor 2)
Heterocephalus glaber (naked mole-rat) : Ryr2 (ryanodine receptor 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01765,533,998 - 65,955,606 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1765,535,403 - 65,955,606 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01767,285,205 - 67,704,766 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41768,959,042 - 69,544,816 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11769,519,966 - 69,552,036 (+)NCBI
Celera1761,573,393 - 61,976,022 (-)NCBICelera
Cytogenetic Map17q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Ryr2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620314
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.