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Gene: Pcsk5 (proprotein convertase subtilisin/kexin type 5) Rattus norvegicus
Symbol: Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Description: Predicted to have peptide binding activity and serine-type endopeptidase activity. Involved in several processes, including positive regulation of integrin-mediated signaling pathway; positive regulation of smooth muscle cell-matrix adhesion; and positive regulation of vascular associated smooth muscle cell migration. Localizes to several cellular components, including Golgi subcompartment; perikaryon; and proximal dendrite. Biomarker of sciatic neuropathy. Orthologous to human PCSK5 (proprotein convertase subtilisin/kexin type 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Pc5; PC6; proprotein convertase 5; proprotein convertase 6; proprotein convertase PC5; rPC5; subtilisin/kexin-like protease PC5
Homo sapiens (human) : PCSK5 (proprotein convertase subtilisin/kexin type 5)  HGNC  Alliance
Mus musculus (house mouse) : Pcsk5 (proprotein convertase subtilisin/kexin type 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pcsk5 (proprotein convertase subtilisin/kexin type 5)
Pan paniscus (bonobo/pygmy chimpanzee) : PCSK5 (proprotein convertase subtilisin/kexin type 5)
Canis lupus familiaris (dog) : PCSK5 (proprotein convertase subtilisin/kexin type 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pcsk5 (proprotein convertase subtilisin/kexin type 5)
Sus scrofa (pig) : PCSK5 (proprotein convertase subtilisin/kexin type 5)
Chlorocebus sabaeus (African green monkey) : PCSK5 (proprotein convertase subtilisin/kexin type 5)
Heterocephalus glaber (naked mole-rat) : Pcsk5 (proprotein convertase subtilisin/kexin type 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01236,031,988 - 236,313,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1236,031,988 - 236,313,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,339,259 - 243,768,026 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41220,961,912 - 221,405,907 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11221,283,956 - 221,569,937 (-)NCBI
Celera1212,298,555 - 212,578,355 (-)NCBICelera
Cytogenetic Map1q51NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pcsk5
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620326
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.