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Gene: Rasgrf1 (RAS protein-specific guanine nucleotide-releasing factor 1) Rattus norvegicus
Symbol: Rasgrf1
Name: RAS protein-specific guanine nucleotide-releasing factor 1
Description: Exhibits Ras GTPase binding activity; protein C-terminus binding activity; and receptor tyrosine kinase binding activity. Involved in several processes, including activation of GTPase activity; positive regulation of fibroblast proliferation; and response to amphetamine. Localizes to several cellular components, including the apical dendrite; apicolateral plasma membrane; and basolateral plasma membrane. Orthologous to human RASGRF1 (Ras protein specific guanine nucleotide releasing factor 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; C60 fullerene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: GNRP; guanine nucleotide-releasing protein; P140 RAS-GRF; ras-GRF1; ras-specific guanine nucleotide-releasing factor 1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0897,277,250 - 97,405,095 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0896,778,440 - 96,905,934 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4894,802,467 - 94,811,501 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1894,955,729 - 94,955,978 (+)NCBI
Celera889,989,217 - 90,117,860 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Rasgrf1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620395
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.