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Gene: Dnm1l (dynamin 1-like) Rattus norvegicus
Symbol: Dnm1l
Name: dynamin 1-like
Description: Exhibits BH2 domain binding activity; clathrin binding activity; and identical protein binding activity. Involved in several processes, including mitochondrion organization; positive regulation of cellular component organization; and synaptic vesicle recycling. Localizes to several cellular components, including bounding membrane of organelle; perinuclear region of cytoplasm; and presynaptic endocytic zone membrane. Colocalizes with clathrin-coated pit and mitochondrial membrane. Biomarker of chronic kidney disease; dental fluorosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (dynamin 1 like); PARTICIPATES IN mitochondria fission pathway; endocytosis pathway; Fc gamma receptor mediated signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
Also known as: C-terminal region; DLP1; Dnml1; Drp1; dynamin-1-like protein; dynamin-like protein 1; dynamin-related protein 1; N-terminal region
Homo sapiens (human) : DNM1L (dynamin 1 like)  HGNC  Alliance
Mus musculus (house mouse) : Dnm1l (dynamin 1-like)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnm1l (dynamin 1 like)
Pan paniscus (bonobo/pygmy chimpanzee) : DNM1L (dynamin 1 like)
Canis lupus familiaris (dog) : DNM1L (dynamin 1 like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnm1l (dynamin 1 like)
Sus scrofa (pig) : DNM1L (dynamin 1 like)
Chlorocebus sabaeus (African green monkey) : DNM1L (dynamin 1 like)
Heterocephalus glaber (naked mole-rat) : Dnm1l (dynamin 1 like)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01188,830,968 - 88,882,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,830,957 - 88,880,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,885,295 - 91,936,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,617,236 - 86,665,861 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,657,172 - 86,706,365 (-)NCBI
Celera1183,326,642 - 83,375,373 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Dnm1l
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620416
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.