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Gene: Sos2 (SOS Ras/Rho guanine nucleotide exchange factor 2) Rattus norvegicus
Symbol: Sos2
Name: SOS Ras/Rho guanine nucleotide exchange factor 2
Description: Predicted to have Ras guanyl-nucleotide exchange factor activity. Involved in positive regulation of small GTPase mediated signal transduction. Predicted to localize to the nucleosome. Human ortholog(s) of this gene implicated in Noonan syndrome 9. Orthologous to human SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2); PARTICIPATES IN insulin signaling pathway; epidermal growth factor/neuregulin signaling pathway; interleukin-6 signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,6-dinitrotoluene; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: son of sevenless 1; son of sevenless homolog 2; son of sevenless homolog 2 (Drosophila); Sos1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0691,885,292 - 92,008,059 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.06101,337,035 - 101,457,580 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4691,609,463 - 91,722,481 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1691,671,060 - 91,684,551 (-)NCBI
Celera686,538,138 - 86,650,990 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Sos2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 620435
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.